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BME 1 Winter Quarter 2020: Project 3 - Point-of-Care Diagnostic Device


URL: https://guides.lib.uci.edu/BME1_Winter2020

Support for Specific Group Projects

Examples of topics that may be selected and appropriate hints & recommendations for databases follow that will serve as strong sources of information:

  1. Brain Computer Interface product - PubMed, Compendex
  2. Tissue Engineered skin for regenerating skin lesions - PubMed, Regenerative Medicine sources, Dermatology sources, Plastic & Cosmetic Surgery sources
  3. Devices for the repair of ligaments and tendons - Sports Medicine; Orthopaedics
  4. Orthopaedic external fixator - Sports Medicine; Orthopaedics; Geriatric Medicine
  5. Percutaneious ventricular restoration technology - Regenerative medicine
  6. Heart Valve replacement - cardiology, thoracic surgery

Outline of Project Summary - Due 3/12

The Project summary outline should include:

  1. Summary page (1p)
    1. company information and device name
    2. problem/disease and significance
    3. current detection strategies
    4. functional & operational details of device (design)
    5. degree of innovation in device
    6. prototyping, testing, regulatory and manufacturing plans
    7. expected costs
  2. Device schematic - (1p, with description of features)
  3. References (1p) in APA format

You may want to consider creating a 3D schematic at the 3D Printing Service in the MRC where there is a small fee to cover printing costs.

 

Schematics, Animations, Videos

Incorporating some multimedia may be of interest to your audience demonstrating how the device functions, what it look like, etc.

Relevant New Books

Project 3 - Point-of-Care Diagnostic Device

In order to work on this project, you are basically writing a business plan to develop the medical device or tissue-engineered product that your group is working on in a new independent start up company that will address the following questions:

  1. what disease to target - can be either infectious or non-infectious, but relevant in the developing world
  2. what critical dimension should be addressed
  3. what is the specific approach for the new device
  4. what would you name your company
  5. what would you name your device - clarifies concept but is still "catchy" to garner attention among the competition

Library Assistance is available by appointments March 2 - 5 and by special appointment by contacting Engineering Librarian - multiple sections can be scheduled at the same time for the same device and can be made at https://tinyurl.com/ybxo5f2e 

Each group is also encouraged to rehearse its presentation by holding a practice session in the Presentation Studio by reserving a time slot.

The project assignment requires that by February 27 each group (same groups as Project 2) will submit the following information:

Choice of medical device or tissue -engineering produce:

  • Tissue-engineered articular cartilage for regenerating focal cartilage lesions
  • Tissue-engineered skin for regenerating skin lesions
  • Device for the repair of ligaments and tendons
  • Orthopaedic external fixator
  • Percutaneous ventricular restoration technology
  • Heart valve replacement

Then you will address the following components as you develop a business plan for your product:

  • what disease and patient base is your group planning to target - Infectious or non-infectious; relevant to the developed or developing world?
  • what critical need are you to focus on addressing?
  • what is the specific approach for the new device?
  • the name of your proposed company that you are forming to undertake this initiative
  • the name for your device - catchy so that it will be remembered and be successful in being sold

Then there are two parts after you determine which device topic to pursue and what each member's new job (leader/manager, marketing, device design, R&D staff, regulatory officer (FDA or equivalent in international/global context) manufacturing, accountant, & presentation editor  will be:

  1. DUE: Tuesday, March 10 - a 3-page summary of the foundation containing on title page:
    1. company information and device name and team members

             on Summary pages (2):

  1.  Paragraph 1 - problem disease - incidence of use & importance
  2. Paragraph 2 - Competitive landscape - current detection strategies
  3. Paragraph 3 - Design - describing functional operational details of device & range of innovation of device
  4. Paragraph 4 - prototyping, testing and manufacturing plans
  5. Paragraph 5 - IP plans and regulatory process (patents, FDA Pathways)
  6. Paragraph 6 - Cost Analysis - expected costs and pricing
  7. Page 2:  product's device schematic - describe features; artistic vision, images
  8. Page 3 - References
  9. DUE March 17 - presentation - following this outline for a 15 minute presentation., including 3 min saved for questions - must submit the powerpoint slides in advance
    1. introduction slide: device, company, employees and jobs (Leader)
    2. impact and scope of disease (Leader)
    3. Current detection strategies in developed & developing world (Leader)
    4. Proposed device (Designer)
    5. Testing plan (R&D Researchers)
    6. Manufacturing plan (Manufacturer/Industrialist)
    7. Summary (Leader)

The jobs to be performed are noted below - choose new roles than you have performed for previous projects and again everyone should be involved in research:

  • leadership (Leader/Manager)
  • device design (Designer)
  • R&D (research and design) (Researchers -2)
  • manufacturing (Manufacturer/Business Contact/Industrialist)
  • market research & evaluation - analysis, customers, innovation (Market Analyst)
  • Cost analysis (Accountant)
  • Summary (Editor)

Things to consider - Hints & Steps to follow for Background Research (list of resources follow):

  1. entire group should review basic background sources may include articles like, "Microfluidic diagnostic technologies for global public health" (Nature, 442/27 July 2006) and another article by the same author, "Point-of-care Diagnostics for Global Health, (Annual Review of Biomedical Engineering, 10: 107-44, 2008).  This realizes a totally different topic but you can see the potential layout.
  2. Assign tasks and coverage for each group member
  3. Select the Disease that your group will address and members will learn about the disease in MedlinePlus, conduct literature searches in PubMed and WoS and other databases about treatment and coverage via diagnostic devices or point-of-care products.  Some point-of-care products such as UpToDate and DynaMed are useful for clinical treatment plans
  4. Select the Geography of developing world that you will help - where in the world will you focus?  A very brief summary of current political, social situation in that country - consult the Europa World Plus and World Bank eAtlas of Global Development, World Bank DataBank and WHO Global Health Estimates and the general World Health Organization (WHO) website that can be searched
  5. Identify diseases and size of population effected - adults, children, how is disease spread, what public health conditions contribute to disease, do people die from this disease - if so, mortality rates
  6. consider disability-adjusted life years for infectious and parasitic diseases (DALYs)
  7. determine what device you are going to develop or promote and conduct a search in PubMed, Compendex, Factiva and Global Market Index for treating that disease - also may want to consult ELDIS
  8. Organizations such as Doctors Without Borders, Project Hope, Save the Children, UNICEF, Engineers Without Borders (International) and Domestic, and other philanthropic charities worldwide are committed to bold initiatives to address healthcare needs of citizens worldwide 
  9. remember what some of the components of a microfluidic diagnostic disposable are:  extremeley low cost, designed to have few parts and be inexpensive to manufacture, ideally using injection moulding whenver possible
  10. Outline business plan and what you plan to share with the Gates Foundation at the "pitch meeting" - look at some of the components in the list of resources under Business Plans below
  11. Business resources may be helpful and several databases are noted below that demonstrate how much consumer health care, medical advances there currently are in those countries or regions you identify - explore the Doing Business in __ depending on what you are looking at, Global Market, Factiva, etc
  12. complete project summary
  13. begin work on presentation and look for images to visually describe your proposal and make sure that you have sufficient data for the designer, manufacturing, testing and marketing specialists on your team

You will want to consult the Images Tab for sources to find images, maps, and other visual content; and then the Presentation Tab for ideas in how to format your presentation.

Resources: The resources listed below include databases - consider what your search strategy should be and make sure that after reading the abstract that you use the UC eLinks to determine if the journal article is available

Background: 

  • Business Plans - a long list of resources both online and in print to help you draft your plan
  • Doing Business Report Series - From the World Bank.  Downloadable reports that objectively measure business regulations and their enforcement across 183 economies and selected cities at the subnational and regional level. The subnational reports exhaustively cover business regulation and reform in different cities and regions within a nation. They provide data on the ease of doing business, rank each location, and recommend reforms to improve performance in each of the indicator areas.
  • an outline of a business plan - customize it for your purposes
     

Other resources follow and you should also consult sources on the Project 2 tab:

Liaison Librarian

Julia Gelfand's picture
Julia Gelfand
Contact:
Office: Science Library 228

Phone: 949-824-4971

EMail: jgelfand@uci.edu

Getting Help - Appointment with Librarian

Please contact Julia Gelfand, Engineering Librarian for an appointment as a group or individually to review information sources and other assistance you need for this assignment.

Outline of Presentation

The outline of the presentation (remember only 15 min including questions) should include:

  1. Executive summary - info about the company, employees and jobs (Leader prepares/presents)
  2. Market analysis - goals, customers, innovation (Marketing Researcher)
  3. Device description: design, prototyping, testing, manufacture, regulatory compliance (Design, R&D, Regulatory, Manufacturing)
  4. Cost analysis (Accountant)
  5. Summary (Editor)

Goal is no more than 1 slide per minute so total slidedeck should contain 10-12 slides in total.

Remember, less text may be more content if visually illustrated well.  Anticipate questions from audience and prepare additional slides that may address those issues. 

Also, consider taking advantage of the Presentation Studio in the MRC to rehearse the Presentation.

3D Printing Options at UCI Library

Options for creating small 3D printing objects at the Multimedia Resource Center  are noted with associated costs and procedures to submit orders.