Evidence-Based Medicine is the integration of best research evidence with clinical expertise and patient values. (Sackett DL, Straus SE, Richardson WS, et al. Evidence-based medicine: how to practice and teach EBM. 2nd ed. Edinburgh: Churchill Livingstone, 2000.)
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Simultaneously searches evidence-based sources of systematic reviews, practice guidelines, and critically-appraised topics and articles -- including most of those listed above and many more. Also searches MEDLINE’s Clinical Queries, medical image databases, e-textbooks, and patient information leaflets.
Filtered resources appraise the quality of studies and often make recommendations for practice.
Authors of a systematic review ask a specific clinical question, perform a comprehensive literature search, eliminate the poorly done studies and attempt to make practice recommendations based on the well-done studies. A meta-analysis is a systematic review that combines all the results of all the studies into a single statistical analysis of results.
- The Cochrane Database of Systematic Reviews (CDSR)* Consists of detailed, structured topic reviews of hundreds of articles. Teams of experts complete comprehensive literature reviews, evaluate the literature, and present summaries of the findings of the best studies. Published by the International Cochrane Collaboration.
- Advanced Search
- Browse by Topic
- Special Collections
- Clinical Answers
Systematic Reviews are also searchable in these sources:
- CINAHL Complete * : Enter your search query. Select “Systematic Reviews” under “Publication Type”.
- PubMed Clinical Queries: Enter your search query in the search box and click search. The Systematic Reviews search results are shown in the Center Column. Move the page down and select See all.
Authors of critically-appraised topics evaluate and synthesize multiple research studies.
Best Practice has been designed and built from the ground up for use specifically as a decision-support tool at the point of care. Latest research evidence, guidelines and expert opinion are combined in a single source and presented in a step-by-step approach, covering prevention, diagnosis, treatment and prognosis. Provides a second opinion, without the need for checking multiple resources.
DynaMed Plus is a medical database that provides access to the most current, evidence-based clinical information on thousands of topics and specialties to healthcare professionals. It provides comprehensive coverage and current, relevant clinical updates, bringing vital knowledge to physicians and healthcare professionals at the point of care. For more information, visit their website.
"Fundamental tools for understanding and applying the medical literature and making clinical diagnoses". Contents include: the Users' guides to the medical literature, Rational clinical examination, and Care at the close of life.
An authoritative source on integrative medicine providing high quality, evidence-based information about complementary and alternative therapies.
A clinical information resource, which offers up-to-date, fully referenced expert answers to patient-care, diagnosis, and treatment questions. Topic reviews are written by recognized authorities who review the topic, synthesize the evidence, summarize key findings, and provide specific recommendations.
Authors of critically-appraised individual articles evaluate and synopsize individual research studies.
The editors of this journal screen the top 100+ clinical journals and identify studies that are methodologically sound and clinically relevant. An enhanced abstract, with conclusions clearly stated, and a commentary are provided for each selected article. Published by the American College of Physicians-American Society of Internal Medicine.
Check EBM e-Journals list for multiple subscriptions.
NEJM Journal Watch
Their mission is to help health care providers efficiently understand medical developments to improve patient care and foster professional development. It is a source that can help you to stay informed and current in your fields. NEJM Journal Watch summarizes the most important research available from over 250 medical journals, as well as other sources of medical news, drug information, public health alerts, and guidelines across 12 specialties and put into perspective for you by their team of physician authors and editors.“Evidence-Based…” Journal series
(e.g., Evidence-Based Medicine, Evidence-Based Mental Health, Evidence-Based Nursing) Primary research articles within the discipline are selected for quality and clinical relevance. A structured abstract and expert commentary are provided for each study.
Check EBM e-Journals list for multiple subscriptions.
Evidence is not always available via filtered resources. Searching the primary literature may be required.
To limit your PubMed search to the best evidence-producing studies: Click on "clinical queries" (on the left side of the screen). This specialized search is intended for clinicians and has built-in search "filters." Four study categories--therapy, diagnosis, etiology, prognosis--are provided, and you may indicate whether you wish your search to be more sensitive (i.e., include most relevant articles but probably including some less relevant ones) or more specific (i.e., including mostly relevant articles but probably omit a few).
International coverage of the professional and academic literature in psychology, medicine, psychiatry, nursing, sociology, education, pharmacology, physiology, linguistics, and other areas.
Click “Browse Methodology” and select the checkbox for “Systematic Reviews”.
CINAHL Complete *
Cumulative Index to Nursing and Allied Health Literature
To limit your CINAHL Complete search to the best evidence-producing studies: select type of “Clinical Queries” or select “Evidence-Based Care Sheet” or “Practice Guidelines” or “Systematic Reviews” in “Publication Type”.
Web of Science consists of seven databases with multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.
BIOSIS Previews is the world's most comprehensive reference database for life science research. It covers original research reports and reviews in traditional biological and biomedical areas. It also covers references to primary journal literature on vital biological research, medical research findings, and discoveries of new organisms.
ClinicalTrials.gov is a registry of federally and privately supported clinical trials conducted in the United States and around the world. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.
Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings. Delivering a comprehensive overview of the world's research output in the fields of science, technology, medicine, social sciences, and arts and humanities, Scopus features smart tools to track, analyze and visualize research database.
Background Information/Expert Opinion
Note: Evidence in these resources may vary from expert opinion to high levels of evidence.
Physician authors and editors contribute to the eMedicine Clinical Knowledge Base, which contains articles on 7,000 diseases and disorders. The evidence-based content provides the latest practice guidelines in 62 medical specialties. eMedicine's professional content undergoes multiple levels of physician peer review.
Full-text electronic books. Check EBM e-Books list for multiple book options.
Searchable and continually updated version of Harrison's Principles of Internal Medicine.